Package: RAMEN 2.99.0


Erick I. Navarro-Delgado
RAMEN: Regional Association of Methylome variability with the Exposome and geNome
RAMEN is an R package which goal is to identify Variable Methylated Loci (VML) in microarray DNA methylation data and then, using genome and exposome data, identify which individual genetic (G) or environmental (E) or joint (G+E or GxE) model better explains the VML variability. This package provides estimates of genetic and environmental contribution for each VML, allowing researchers to gain insights into the complex interplay between genetics, environment and DNA methylation.
Authors:
RAMEN_2.99.0.tar.gz
RAMEN_2.99.0.zip(r-4.7-any)RAMEN_2.99.0.zip(r-4.6-any)RAMEN_2.1.2.zip(r-4.5-any)
RAMEN_2.99.0.tgz(r-4.6-any)RAMEN_2.1.2.tgz(r-4.5-any)
RAMEN_2.99.0.tar.gz(r-4.7-any)RAMEN_2.99.0.tar.gz(r-4.6-any)
RAMEN_2.99.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
RAMEN/json (API)
| # Install 'RAMEN' in R: |
| install.packages('RAMEN', repos = c('https://packages.ropensci.org', 'https://cloud.r-project.org')) |
Reviews:rOpenSci Software Review #743
Bug tracker:https://github.com/ropensci/ramen/issues
Pkgdown/docs site:https://ropensci.github.io
- test_covariates - Concomitant variable example data set
- test_environmental_matrix - Environmental exposures example data set
- test_genotype_information - Genotype metadata example data set
- test_genotype_matrix - Genotype matrix example
- test_methylation_data - Methylation data matrix example
- ultrastable_cpgs - Ultrastable probes
dnamethylationgenomewideassociationepigeneticsregressionsnpmicroarraymethylationarraygeneticvariabilitybioinformatics-tooldna-methylationexposomegenomemethylation-analysismethylation-microarraysmultiomics
Last updated from:57405c7c84 (on main). Checks:8 OK, 2 FAIL. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel | OK | 1145 | ||
| pkgdown docs | OK | 1406 | ||
| source / vignettes | OK | 993 | ||
| linux-release | OK | 1174 | ||
| macos-release | OK | 1209 | ||
| macos-oldrel | FAIL | 938 | ||
| windows-devel | OK | 2420 | ||
| windows-release | OK | 3304 | ||
| windows-oldrel | FAIL | 2497 | ||
| wasm-release | OK | 926 |
Exports:findCisSNPsfindVMLlmGEmedCorVMRnullDistGEselectVariablessummarizeVML
Dependencies:abindannotateAnnotationDbiaskpassbase64beanplotBHBiobaseBiocBaseUtilsBiocFileCacheBiocGenericsBiocIObiocmakeBiocParallelBiostringsbitbit64bitopsblobbootbumphuntercachemcigarilloclicliprcodetoolscorpcorcpp11crayoncurldata.tableDBIdbplyrDelayedArrayDelayedMatrixStatsdigestdir.expirydoRNGdplyrfastmapfilelockforeachformatRfutile.loggerfutile.optionsgenefiltergenericsGenomicAlignmentsGenomicFeaturesGenomicRangesGEOqueryglmnetglueh5mreadHDF5Arrayhmshttrhttr2IlluminaHumanMethylationEPICanno.ilm10b4.hg19illuminaioIRangesiteratorsjsonliteKEGGRESTlambda.rlatticelifecyclelimmalocfitmagrittrMASSMatrixMatrixGenericsmatrixStatsmclustmemoisemimeminfiminqamitoolsmulttestnlmenor1mixnumDerivopensslpillarpkgconfigplyrpngpreprocessCoreprettyunitsprogresspurrrquadprogR.methodsS3R.ooR.utilsR6RColorBrewerRcppRcppArmadilloRcppEigenRCurlreadrrelaimporentrezreshaperestfulrrhdf5rhdf5filtersRhdf5libRhtslibrjsonrlangrngtoolsRsamtoolsRSQLitertracklayerrvestS4ArraysS4VectorsscrimeselectrSeqinfoshapesiggenessnowSparseArraysparseMatrixStatsstatmodstringistringrSummarizedExperimentsurveysurvivalsystibbletidyrtidyselecttzdbutf8vctrsvroomwithrXMLxml2xtableXVectoryaml
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Find cis SNPs around a set of Variable Methylated Loci (VML) | findCisSNPs |
| Identify Variable Methylated Loci in microarrays | findVML |
| Fit linear G, E, G+E and GxE models and select the winning model | lmGE |
| Compute the median probe methylation pearson correlation for each Variable Methylated Region (VMR). | medCorVMR |
| Simulate a delta R squared null distribution of G and E effects on DNAme variability | nullDistGE |
| Selection of relevant environment and genotype variables associated with Variably Methylated Loci (VML) | selectVariables |
| Summarize the methylation states of Variable Methylated Loci (VML) | summarizeVML |
| Concomitant variable example data set | test_covariates |
| Environmental exposures example data set | test_environmental_matrix |
| Genotype metadata example data set | test_genotype_information |
| Genotype matrix example | test_genotype_matrix |
| Methylation data matrix example | test_methylation_data |
| Ultrastable probes | ultrastable_cpgs |